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1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor.
Gu, Wan-gang; Ip, Denis Tsz-Ming; Liu, Si-jie; Chan, Joseph H; Wang, Yan; Zhang, Xuan; Zheng, Yong-tang; Wan, David Chi-Cheong.
Afiliação
  • Gu WG; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China; Department of Immunology, Zunyi Medical College, Zunyi, China.
  • Ip DT; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.
  • Liu SJ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.
  • Chan JH; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.
  • Wang Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China.
  • Zhang X; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
  • Wan DC; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China. Electronic address: chicheongwan@cuhk.edu.hk.
Chem Biol Interact ; 213: 21-7, 2014 Apr 25.
Article em En | MEDLINE | ID: mdl-24480521
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / HIV-1 / Inibidores de Integrase de HIV / Integrase de HIV / Peptídeos e Proteínas de Sinalização Intercelular / Naftalenos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiofenos / HIV-1 / Inibidores de Integrase de HIV / Integrase de HIV / Peptídeos e Proteínas de Sinalização Intercelular / Naftalenos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Chem Biol Interact Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China