Multi-algorithm and multi-model based drug target prediction and web server.
Acta Pharmacol Sin
; 35(3): 419-31, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24487966
ABSTRACT
AIM:
To develop a reliable computational approach for predicting potential drug targets based merely on protein sequence.METHODS:
With drug target and non-target datasets prepared and 3 classification algorithms (Support Vector Machine, Neural Network and Decision Tree), a multi-algorithm and multi-model based strategy was employed for constructing models to predict potential drug targets.RESULTS:
Twenty one prediction models for each of the 3 algorithms were successfully developed. Our evaluation results showed that â¼30% of human proteins were potential drug targets, and â¼40% of putative targets for the drugs undergoing phase II clinical trials were probably non-targets. A public web server named D3TPredictor (http//www.d3pharma.com/d3tpredictor) was constructed to provide easy access.CONCLUSION:
Reliable and robust drug target prediction based on protein sequences is achieved using the multi-algorithm and multi-model strategy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Desenho Assistido por Computador
/
Internet
/
Proteoma
/
Bases de Dados de Proteínas
/
Descoberta de Drogas
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Acta Pharmacol Sin
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China