Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.
Chemistry
; 20(12): 3306-10, 2014 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-24519660
ABSTRACT
Very high diastereoselectivity can be achieved by 1,3-chelation-controlled allylation of aldehydes that possess a non-chelating α-ether substituent, even if the α-position is a quaternary centre and/or a spiro-epoxide. This reaction was used as a key step in an enantioselective synthesis of the angiogenesis inhibitor luminacinâ
D.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Espiro
/
Benzaldeídos
/
Quelantes
/
Aldeídos
/
Compostos de Epóxi
/
Éter
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article