Partial characterization of suppressor factors in spleen cell culture supernatants of Mycobacterium lepraemurium-infected mice.
Adv Exp Med Biol
; 239: 279-85, 1988.
Article
em En
| MEDLINE
| ID: mdl-2462335
ABSTRACT
Suppressor factors (SF) were released into the culture supernatant when spleen cells from M. lepraemurium-infected C57BL/6 mice were incubated at 37 degrees C in the absence of any inducing agents. Some of the SF appeared to be specific in that they inhibited the blastogenic response to mycobacterial antigens by opposition to the others which inhibited the blastogenic responses to PHA, Con A and LPS. All SF seemed to be produced in a cyclic manner. In mice infected 9 weeks earlier, the release of "specific" SF occurred early (4-8 h) during the incubation period whereas, the nonspecific SF were released later on (12-32 h). Adoptive transfers of SF-containing culture supernatants depressed the expression of DTH to M.1m antigens but not its induction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Frações Subcelulares
/
Sistema Livre de Células
/
Fatores Supressores Imunológicos
/
Infecções por Mycobacterium
Limite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
1988
Tipo de documento:
Article