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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
Barrett, Stephanie E; Burke, Rob S; Abrams, Marc T; Bason, Carol; Busuek, Marina; Carlini, Edward; Carr, Brian A; Crocker, Louis S; Fan, Haihong; Garbaccio, Robert M; Guidry, Erin N; Heo, Jun H; Howell, Bonnie J; Kemp, Eric A; Kowtoniuk, Robert A; Latham, Andrew H; Leone, Anthony M; Lyman, Michael; Parmar, Rubina G; Patel, Mihir; Pechenov, Sergey Y; Pei, Tao; Pudvah, Nicole T; Raab, Conrad; Riley, Sean; Sepp-Lorenzino, Laura; Smith, Sheri; Soli, Eric D; Staskiewicz, Steven; Stern, Melissa; Truong, Quang; Vavrek, Marissa; Waldman, Jacob H; Walsh, Eileen S; Williams, J Michael; Young, Stephanie; Colletti, Steven L.
Afiliação
  • Barrett SE; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: stephanie_barrett@merck.com.
  • Burke RS; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Abrams MT; Department of RNA Biology, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Bason C; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Busuek M; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Carlini E; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Carr BA; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Crocker LS; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Fan H; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Garbaccio RM; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Guidry EN; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Heo JH; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Howell BJ; Department of RNA Biology, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Kemp EA; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Kowtoniuk RA; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Latham AH; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Leone AM; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Lyman M; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Parmar RG; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Patel M; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Pechenov SY; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Pei T; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Pudvah NT; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Raab C; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Riley S; Department of RNAi Analytical Sciences, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Sepp-Lorenzino L; Department of RNA Biology, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Smith S; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Soli ED; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Staskiewicz S; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Stern M; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Truong Q; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Vavrek M; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Waldman JH; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA.
  • Walsh ES; Department of RNA Biology, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Williams JM; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Young S; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
  • Colletti SL; Department of RNA Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., West Point, PA 19486, USA.
J Control Release ; 183: 124-37, 2014 Jun 10.
Article em En | MEDLINE | ID: mdl-24657948
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Materiais Biocompatíveis / Portadores de Fármacos / RNA Interferente Pequeno / Fígado / Nylons Limite: Animals / Female / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Materiais Biocompatíveis / Portadores de Fármacos / RNA Interferente Pequeno / Fígado / Nylons Limite: Animals / Female / Humans Idioma: En Revista: J Control Release Assunto da revista: FARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article