Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Huber, Kilian V M; Salah, Eidarus; Radic, Branka; Gridling, Manuela; Elkins, Jonathan M; Stukalov, Alexey; Jemth, Ann-Sofie; Göktürk, Camilla; Sanjiv, Kumar; Strömberg, Kia; Pham, Therese; Berglund, Ulrika Warpman; Colinge, Jacques; Bennett, Keiryn L; Loizou, Joanna I; Helleday, Thomas; Knapp, Stefan; Superti-Furga, Giulio

Huber, Kilian V M; Salah, Eidarus; Radic, Branka; Gridling, Manuela; Elkins, Jonathan M; Stukalov, Alexey; Jemth, Ann-Sofie; Göktürk, Camilla; Sanjiv, Kumar; Strömberg, Kia; Pham, Therese; Berglund, Ulrika Warpman; Colinge, Jacques; Bennett, Keiryn L; Loizou, Joanna I; Helleday, Thomas; Knapp, Stefan; Superti-Furga, Giulio.

Afiliação

Huber KV; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Salah E; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Radic B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Gridling M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Elkins JM; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Stukalov A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Göktürk C; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Sanjiv K; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Strömberg K; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Pham T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Berglund UW; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Colinge J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Bennett KL; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Loizou JI; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17121 Stockholm, Sweden.
Knapp S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

Nature ; 508(7495): 222-7, 2014 Apr 10.

Article em En | MEDLINE | ID: mdl-24695225

Assuntos

Antineoplásicos/farmacologia; Enzimas Reparadoras do DNA/antagonistas & inibidores; Enzimas Reparadoras do DNA/metabolismo; Monoéster Fosfórico Hidrolases/antagonistas & inibidores; Monoéster Fosfórico Hidrolases/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/farmacologia; Piridinas/farmacologia; Aminoquinolinas/farmacologia; Animais; Antineoplásicos/química; Neoplasias do Colo/tratamento farmacológico; Neoplasias do Colo/genética; Neoplasias do Colo/patologia; Crizotinibe; Cristalização; Quebras de DNA de Cadeia Simples/efeitos dos fármacos; Reparo do DNA; Enzimas Reparadoras do DNA/biossíntese; Enzimas Reparadoras do DNA/química; Modelos Animais de Doenças; Feminino; Homeostase/efeitos dos fármacos; Humanos; Camundongos; Camundongos SCID; Modelos Moleculares; Nucleotídeos/metabolismo; Monoéster Fosfórico Hidrolases/biossíntese; Monoéster Fosfórico Hidrolases/química; Conformação Proteica; Inibidores de Proteínas Quinases/química; Proteômica; Proteínas Proto-Oncogênicas/genética; Proteínas Proto-Oncogênicas p21(ras); Pirazóis/química; Piridinas/química; Especificidade por Substrato; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas ras/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Monoéster Fosfórico Hidrolases / Enzimas Reparadoras do DNA / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Revista: Nature Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Áustria

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