Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy.
Braz J Med Biol Res
; 47(5): 432-7, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24760119
ABSTRACT
It is not known whether the addition of ezetimibe to statins adds cardiovascular protection beyond the expected changes in lipid levels. Subjects with coronary heart disease were treated with four consecutive 1-week courses of therapy (T) and evaluations. The courses were T1, 100 mg aspirin alone; T2, 100 mg aspirin and 40 mg simvastatin/10 mg ezetimibe; T3, 40 mg simvastatin/10 mg ezetimibe, and 75 mg clopidogrel (300 mg initial loading dose); T4, 75 mg clopidogrel alone. Platelet aggregation was examined in whole blood. Endothelial microparticles (CD51), platelet microparticles (CD42/CD31), and endothelial progenitor cells (CD34/CD133; CDKDR/CD133, or CD34/KDR) were quantified by flow cytometry. Endothelial function was examined by flow-mediated dilation. Comparisons between therapies revealed differences in lipids (T2 and T3
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Agregação Plaquetária
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Sinvastatina
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Doença das Coronárias
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Micropartículas Derivadas de Células
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Células Progenitoras Endoteliais
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil