Phosphorylation of tyrosine prevents dityrosine formation in vitro.
FEBS Lett
; 255(2): 395-7, 1989 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-2477282
ABSTRACT
Treatment of L-tyrosine in a peroxidase/H2O2 system results in the formation of dityrosine. However, the phosphoester derivative of tyrosine, O-phospho-L-tyrosine, was unable to form dityrosine even in mixtures with free L-tyrosine. Dephosphorylation of O-phospho-L-tyrosine by alkaline phosphatase followed by horseradish peroxidase/H2O2 treatment resulted in the formation of dityrosine. Our in vitro results indicate that phosphorylation/dephosphorylation of L-tyrosine may regulate dityrosine formation, and is supposed to play an important role in protein-protein interactions, i.e. cross-linking.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Áustria