Thyroid transcription factor-1 is a specific marker of benign but not malignant feline lung tumours.
J Comp Pathol
; 151(1): 19-24, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24813152
ABSTRACT
Feline lung tumours are currently subclassified according to the criteria of the World Health Organisation, but this scheme contains overlap in the tumour phenotype. The aims of the present study were to re-evaluate the histological features of feline lung tumours and to correlate these with expression of the markers thyroid transcription factor (TTF)-1 and Ki67. TTF-1 was found to be a highly specific marker for neoplastic and non-neoplastic lung tissue and thyroid tissue, but was expressed only weakly in invasive lung tumours. A combined semiquantitative score for Ki67 and TTF-1 expression correlated well with differentiation and invasive behaviour of the tumours and may thus be of potential value for evaluation of feline lung tumours.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
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Doenças do Gato
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Biomarcadores Tumorais
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Neoplasias Pulmonares
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha