Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways.

Aghajanian, Haig; Choi, Connie; Ho, Vivienne C; Gupta, Mudit; Singh, Manvendra K; Epstein, Jonathan A

Aghajanian, Haig; Choi, Connie; Ho, Vivienne C; Gupta, Mudit; Singh, Manvendra K; Epstein, Jonathan A.

Afiliação

Aghajanian H; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Choi C; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Ho VC; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Gupta M; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Singh MK; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Epstein JA; From the Department of Cell and Developmental Biology and the Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 epsteinj@upenn.edu.

J Biol Chem ; 289(26): 17971-9, 2014 Jun 27.

Article em En | MEDLINE | ID: mdl-24825896

Assuntos

Movimento Celular; Células Endoteliais/citologia; Células Endoteliais/metabolismo; Glicoproteínas/metabolismo; Proteínas de Membrana/metabolismo; Semaforinas/metabolismo; Transdução de Sinais; Animais; Moléculas de Adesão Celular Neuronais/genética; Moléculas de Adesão Celular Neuronais/metabolismo; Proteínas do Citoesqueleto; Citoesqueleto/genética; Citoesqueleto/metabolismo; Células Endoteliais/enzimologia; Feminino; Glicoproteínas/genética; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular; Masculino; Glicoproteínas de Membrana; Proteínas de Membrana/genética; Camundongos; Camundongos Knockout; Proteínas do Tecido Nervoso; Neuropilina-1/genética; Neuropilina-1/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Semaforinas/genética; Proteína Smad3/genética; Proteína Smad3/metabolismo

Palavras-chave

Actin; Akt; Cell Motility; Endothelial Cell; Neuropilin; PI3K; Plexin; Semaphorin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas / Transdução de Sinais / Movimento Celular / Semaforinas / Células Endoteliais / Proteínas de Membrana Limite: Animals / Female / Humans / Male Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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