Synthesis and bioactivity of diketopiperazine PJ147 and its derivatives from Gliocladium sp. YUP08.
J Asian Nat Prod Res
; 16(7): 764-9, 2014.
Article
em En
| MEDLINE
| ID: mdl-24827395
ABSTRACT
Concise total synthesis of diketopiperazine PJ147, obtained from mycelium of Gliocladium sp. YUP08, has been achieved in seven steps with 43.5% overall yield. Biological evaluation of PJ147 exhibited strong inhibiting activity against A375-S2, Hela, P388, A-549, HL-60, and BEL-7420 cell lines. Thus, eight derivatives of PJ147 with high water solubility were also synthesized to facilitate the in vivo bioassay of this kind of diketopiperazines.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gliocladium
/
Dicetopiperazinas
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Asian Nat Prod Res
Assunto da revista:
BOTANICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China