Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex.

Mnpotra, Jagjeet S; Qiao, Zhuanhong; Cai, Jian; Lynch, Diane L; Grossfield, Alan; Leioatts, Nicholas; Hurst, Dow P; Pitman, Michael C; Song, Zhao-Hui; Reggio, Patricia H

Mnpotra, Jagjeet S; Qiao, Zhuanhong; Cai, Jian; Lynch, Diane L; Grossfield, Alan; Leioatts, Nicholas; Hurst, Dow P; Pitman, Michael C; Song, Zhao-Hui; Reggio, Patricia H.

Afiliação

Mnpotra JS; From the Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27402.
Qiao Z; the Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292.
Cai J; the Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292.
Lynch DL; From the Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27402.
Grossfield A; the Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, and.
Leioatts N; the Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, and.
Hurst DP; From the Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27402.
Pitman MC; From the Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27402, the Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598.
Song ZH; the Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, zhsong@louisville.edu.
Reggio PH; From the Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, North Carolina 27402, phreggio@uncg.edu.

J Biol Chem ; 289(29): 20259-72, 2014 Jul 18.

Article em En | MEDLINE | ID: mdl-24855641

Assuntos

Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/química; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Receptor CB2 de Canabinoide/química; Receptor CB2 de Canabinoide/metabolismo; Cromatografia Líquida; Reagentes de Ligações Cruzadas; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/genética; Células HEK293; Humanos; Modelos Moleculares; Simulação de Dinâmica Molecular; Complexos Multiproteicos/química; Complexos Multiproteicos/metabolismo; Conformação Proteica; Domínios e Motivos de Interação entre Proteínas; Mapeamento de Interação de Proteínas; Estrutura Secundária de Proteína; Receptor CB2 de Canabinoide/genética; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Espectrometria de Massas por Ionização por Electrospray; Espectrometria de Massas em Tandem

Palavras-chave

Cannabinoid Receptor; G Protein-coupled Receptor (GPCR); Mass Spectrometry (MS); Molecular Dynamics; Signal Transduction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP / Receptor CB2 de Canabinoide Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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