Examining the impact of gene variants on histone lysine methylation.
Biochim Biophys Acta
; 1839(12): 1463-76, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-24859469
ABSTRACT
In recent years, there has been a boom in the amount of genome-wide sequencing data that has uncovered important and unappreciated links between certain genes, families of genes and enzymatic processes and diseases such as cancer. Such studies have highlighted the impact that chromatin modifying enzymes could have in cancer and other genetic diseases. In this review, we summarize characterized mutations and single nucleotide polymorphisms (SNPs) in histone lysine methyltransferases (KMTs), histone lysine demethylases (KDMs) and histones. We primarily focus on variants with strong disease correlations and discuss how they could impact histone lysine methylation dynamics and gene regulation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Histona-Lisina N-Metiltransferase
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Polimorfismo de Nucleotídeo Único
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Histona Desmetilases
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Lisina
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Mutação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos