Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.

Kim, Minjung; Lee, Junghun; Jung, Kyungjin; Kim, Hyangmi; Aman, Waqar; Ryu, Jae-Sang; Hah, Jung-Mi

Kim, Minjung; Lee, Junghun; Jung, Kyungjin; Kim, Hyangmi; Aman, Waqar; Ryu, Jae-Sang; Hah, Jung-Mi.

Afiliação

Kim M; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea.
Lee J; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea.
Jung K; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea.
Kim H; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea.
Aman W; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea.
Ryu JS; College of Pharmacy & Graduate School of Pharmaceutical Sciences, Global Top 5 Research Program, Ewha Womans University, 11-1 Daehyun-Dong, Seodaemun-Gu, Seoul 120-750, Republic of Korea.
Hah JM; Department of Pharmacy, College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Kyeonggi-do 426-791, Republic of Korea. Electronic address: jhah@hanyang.ac.kr.

Bioorg Med Chem Lett ; 24(15): 3600-4, 2014 Aug 01.

Article em En | MEDLINE | ID: mdl-24878193

Assuntos

Antineoplásicos/farmacologia; Desenho de Fármacos; Compostos de Fenilureia/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Pirimidinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Modelos Moleculares; Estrutura Molecular; Compostos de Fenilureia/síntese química; Compostos de Fenilureia/química; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Proteínas Proto-Oncogênicas B-raf/metabolismo; Pirimidinas/síntese química; Pirimidinas/química; Relação Estrutura-Atividade; Células U937

Palavras-chave

(4-Aminobenzyl)-1H-imidazol-1-yl pyrimidin-2-yl derivatives; Antiproliferative activity; BRAF V600E; CRAF; Melanoma; Selectivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Pirimidinas / Desenho de Fármacos / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article

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