Regulation of energy metabolism by the skeleton: osteocalcin and beyond.
Arch Biochem Biophys
; 561: 137-46, 2014 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-24893146
ABSTRACT
The skeleton has recently emerged as an endocrine organ implicated in the regulation of glucose and energy metabolism. This function of bone is mediated, at least in part, by osteocalcin, an osteoblast-derived protein acting as a hormone stimulating insulin sensitivity, insulin secretion and energy expenditure. Osteocalcin secretion and bioactivity is in turn regulated by several hormonal cues including insulin, leptin, the sympathetic nervous system and glucocorticoids. Recent findings support the notion that osteocalcin functions and regulations are conserved between mice and humans. Moreover, studies in mice suggest that osteocalcin could represent a viable therapeutic approach for the treatment of obesity and insulin resistance. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osso e Ossos
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Resistência à Insulina
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Osteocalcina
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Metabolismo Energético
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Glucose
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Homeostase
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Insulina
Limite:
Animals
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Humans
Idioma:
En
Revista:
Arch Biochem Biophys
Ano de publicação:
2014
Tipo de documento:
Article