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Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.
Wichmann, C; Quagliano-Lo Coco, I; Yildiz, Ö; Chen-Wichmann, L; Weber, H; Syzonenko, T; Döring, C; Brendel, C; Ponnusamy, K; Kinner, A; Brandts, C; Henschler, R; Grez, M.
Afiliação
  • Wichmann C; 1] Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany [2] Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany.
  • Quagliano-Lo Coco I; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Yildiz Ö; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Chen-Wichmann L; 1] Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany [2] Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany.
  • Weber H; 1] Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany [2] BIOREN - CEGIN, Molecular Pathology Laboratory, Department of Pathology, School of Medicine, Universidad de La Frontera, Temuco, Chile.
  • Syzonenko T; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Döring C; Dr Senckenberg Institute of Pathology, Goethe University, Frankfurt, Germany.
  • Brendel C; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Ponnusamy K; 1] Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany [2] Institute of Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany.
  • Kinner A; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
  • Brandts C; Department of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.
  • Henschler R; 1] Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, Ludwig-Maximilian University Hospital, Munich, Germany [2] Institute of Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany.
  • Grez M; Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
Leukemia ; 29(2): 279-89, 2015 Feb.
Article em En | MEDLINE | ID: mdl-24897507
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Células-Tronco Hematopoéticas / Proteínas de Fusão Oncogênica / Apoptose / Proteínas Proto-Oncogênicas c-kit / Subunidade alfa 2 de Fator de Ligação ao Core Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Células-Tronco Hematopoéticas / Proteínas de Fusão Oncogênica / Apoptose / Proteínas Proto-Oncogênicas c-kit / Subunidade alfa 2 de Fator de Ligação ao Core Limite: Humans Idioma: En Revista: Leukemia Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Alemanha