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Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.
Yang, Zhi-Qiang; Shu, Youheng; Ma, Lei; Wittmann, Marion; Ray, William J; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Hartman, George D; Bilodeau, Mark T; Kuduk, Scott D.
Afiliação
  • Yang ZQ; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Shu Y; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Ma L; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Wittmann M; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Ray WJ; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Seager MA; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Koeplinger KA; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Thompson CD; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Hartman GD; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Bilodeau MT; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Kuduk SD; Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories , Sumneytown Pike, West Point, Pennsylvania 19486, United States.
ACS Med Chem Lett ; 5(5): 604-8, 2014 May 08.
Article em En | MEDLINE | ID: mdl-24900888
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos