A continuous flow method for estimation of drug release rates from emulsion formulations.
Int J Pharm
; 472(1-2): 276-81, 2014 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-24945139
ABSTRACT
We present a continuous-flow method that allows the release of drugs from submicron colloidal carriers to be estimated on a millisecond timescale. The technique is applied to the study of release of a model drug (tetracaine) from lipid emulsions, and shows that the solute drug is released in this timescale, and thus is primarily controlled by the rapid diffusion of the drug within the oil droplet. This confirms our previous claims that existing methods, such as dialysis or centrifugation, are too slow to provide useful release data for drug-containing emulsions, and demonstrates that it is unlikely that a simple emulsion could be used as a circulating sustained-release formulation, as has been suggested by some workers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Emulsões
/
Liberação Controlada de Fármacos
Idioma:
En
Revista:
Int J Pharm
Ano de publicação:
2014
Tipo de documento:
Article