Feasibility of gadoxetate disodium-enhanced MR cholangiography in chronic cholestatic biliary disease.
Clin Radiol
; 69(10): 1027-33, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24957855
ABSTRACT
AIM:
To investigate the feasibility of gadoxetate disodium-enhanced magnetic resonance (MR) cholangiography in chronic obstructive cholestatic biliary disease in the clinical setting. MATERIALS ANDMETHODS:
Twenty-three patients with dilated bile duct trees and ten volunteers underwent gadoxetate disodium-enhanced liver MR cholangiography and were enrolled in the present retrospective study. Gadoxetate disodium was given in a standardized manner as a bolus injection at a dose of 0.25 mmol/kg of body weight (0.1 ml/kg). Region of interest-based measurement of mean enhancement of the dilated bile ducts was performed in series before gadoxetate disodium administration and during hepatobiliary phases.RESULTS:
Direct comparison of mean bile duct enhancement during hepatobiliary phases in the clinical imaging window between healthy volunteers [4.7 ± 2.2 arbitrary units (au)] and patients with dilated bile ducts (0.1 ± 0.3 au) revealed significantly lower or absent enhancement in dilated bile ducts (p = 0.001).CONCLUSION:
Standard clinical gadoxetate disodium-enhanced MR cholangiography is not a reliable technique for the evaluation of the biliary trees, because of altered biliary gadoxetate disodium elimination in patients with chronic obstructive biliary diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Ductos Biliares
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Imageamento por Ressonância Magnética
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Colangiografia
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Aumento da Imagem
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Meios de Contraste
/
Gadolínio DTPA
Tipo de estudo:
Diagnostic_studies
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Observational_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Clin Radiol
Ano de publicação:
2014
Tipo de documento:
Article