Characteristics of canonical intrinsic connectivity networks across tasks and monozygotic twin pairs.
Hum Brain Mapp
; 35(11): 5532-49, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-24984861
ABSTRACT
Intrinsic connectivity networks (ICNs) are becoming more prominent in the analyses of in vivo brain activity as the field of neurometrics has revealed their importance for augmenting traditional cognitive neuroscience approaches. Consequently, tools that assess the coherence, or connectivity, and morphology of ICNs are being developed to support inferences and assumptions about the dynamics of the brain. Recently, we reported trait-like profiles of ICNs showing reliability over time and reproducibility across different contexts. This study further examined the trait-like and familial nature of ICNs by utilizing two divergent task paradigms in twins. The study aimed to identify stable network phenotypes that exhibited sensitivity to individual differences and external perturbations in task demands. Analogous ICNs were detected in each task and these ICNs showed consistency in morphology and intranetwork coherence across tasks, whereas the ICN timecourse dynamics showed sensitivity to task demands. Specifically, the timecourse of an arm/hand sensorimotor network showed the strongest correlation with the timeline of a hand imitation task, and the timecourse of a language-processing network showed the strongest temporal association with a verb generation task. The area V1/simple visual stimuli network exhibited the most consistency in morphology, coherence, and timecourse dynamics within and across tasks. Similarly, this network exhibited familiality in all three domains as well. Hence, this experiment is a proof of principle that the morphology and coherence of ICNs can be consistent both within and across tasks, that ICN timecourses can be differentially and meaningfully modulated by a task, and that these domains can exhibit familiality.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gêmeos Monozigóticos
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Encéfalo
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Mapeamento Encefálico
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Cognição
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Rede Nervosa
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Vias Neurais
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2014
Tipo de documento:
Article