Combined value of susceptibility-weighted and perfusion-weighted imaging in assessing who grade for brain astrocytomas.
J Magn Reson Imaging
; 39(6): 1569-74, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24987755
ABSTRACT
PURPOSE:
To assess the value of combining susceptibility-weighted imaging (SWI) and dynamic susceptibility weighted contrast-enhanced (DSC) perfusion-weighted MRI (PWI) in assessing World Health Organization (WHO)grade for brain astrocytoma . MATERIALS ANDMETHODS:
A total of 94 patients with pathologically confirmed astrocytomas underwent SWI and DSC scans. The evaluation included intratumoral susceptibility signal intensity (ITSS) and relative cerebral blood volume (rCBV) max. The receiver operating characteristic curve (ROC) was used to assess the efficacy of combining two sequences in astrocytoma grading.RESULTS:
ITSS within astrocytomas showed significant correlations with rCBV max (r » 0.72; P < 0.01) and with tumor grades (r » 0.92; P < 0.01), and there was also a significant correlation between rCBV and tumor grade (r= 0.77; P < 0.001). The area under the ROC, SWI, PWI,SWI, and PWI, in differentiation of the grades II and III astrocytomas were 0.995, 0.942, and 1.000, respectively;identifying grades III and IV were 0.773, 0.919, and 0.978, respectively; and identifying high and low-grade astrocytomas were 0.999, 0.992, 1.000, respectively.CONCLUSION:
ITSS was useful for assessing the WHO tumor grade in this cohort of patients with astrocytoma.The combination of SWI and PWI may improve the diagnostic accuracy of astrocytoma grading.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Astrocitoma
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Organização Mundial da Saúde
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Neoplasias Encefálicas
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Imageamento por Ressonância Magnética
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Angiografia por Ressonância Magnética
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Imagem Multimodal
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China