Ameliorative effect of Matricaria chamomilla .L on paraquat: Induced oxidative damage in lung rats.
Pharmacognosy Res
; 6(3): 199-203, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-25002799
ABSTRACT
BACKGROUND:
Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity. MATERIALS ANDMETHODS:
Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured.RESULTS:
In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx.CONCLUSION:
M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Pharmacognosy Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Irã