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The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
Davis, Oliver S P; Band, Gavin; Pirinen, Matti; Haworth, Claire M A; Meaburn, Emma L; Kovas, Yulia; Harlaar, Nicole; Docherty, Sophia J; Hanscombe, Ken B; Trzaskowski, Maciej; Curtis, Charles J C; Strange, Amy; Freeman, Colin; Bellenguez, Céline; Su, Zhan; Pearson, Richard; Vukcevic, Damjan; Langford, Cordelia; Deloukas, Panos; Hunt, Sarah; Gray, Emma; Dronov, Serge; Potter, Simon C; Tashakkori-Ghanbaria, Avazeh; Edkins, Sarah; Bumpstead, Suzannah J; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Duncanson, Audrey; Jankowski, Janusz A Z; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Barroso, Ines; Peltonen, Leena; Dale, Philip S; Petrill, Stephen A; Schalkwyk, Leonard S; Craig, Ian W; Lewis, Cathryn M; Price, Thomas S; Donnelly, Peter.
Afiliação
  • Davis OS; 1] Department of Genetics, Evolution and Environment, UCL Genetics Institute, University College London, London WC1E 6BT, UK [2] King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK [3].
  • Band G; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2].
  • Pirinen M; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2].
  • Haworth CM; 1] King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK [2] Department of Psychology, University of Warwick, Coventry CV4 7AL, UK.
  • Meaburn EL; Department of Psychological Sciences, Birkbeck, University of London, London WC1E 7HX, UK.
  • Kovas Y; Department of Psychology, Goldsmiths, University of London, London SE14 6NW, UK.
  • Harlaar N; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA.
  • Docherty SJ; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Hanscombe KB; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Trzaskowski M; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Curtis CJ; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Strange A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Freeman C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Bellenguez C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Su Z; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Pearson R; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Vukcevic D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Langford C; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Deloukas P; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Hunt S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Gray E; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Dronov S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Potter SC; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Tashakkori-Ghanbaria A; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Edkins S; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Bumpstead SJ; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Blackwell JM; 1] Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, Western Australia, Australia [2] Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge CB2 0XY, UK.
  • Bramon E; 1] UCL Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK [2] UCL Mental Health Sciences Unit, University College London, London W1W 7EJ, UK.
  • Brown MA; University of Queensland Diamantia Institute, Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland QLD 4102, Australia.
  • Casas JP; 1] Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK [2] Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Corvin A; Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland.
  • Duncanson A; Molecular and Physiological Sciences, The Wellcome Trust, London NW1 2BE, UK.
  • Jankowski JA; 1] Centre for Digestive Diseases, Blizard Institute, Queen Mary University of London, London E1 2AT, UK [2] Wolfson College, Linton Road, Oxford OX2 6UD, UK [3] Peninsula School of Medicine and Dentistry, Associate Deans Office, John Bull Building, Plymouth PL6 8BU, UK.
  • Markus HS; Clinical Neurosciences, Saint George's University of London, London SW17 0RE, UK.
  • Mathew CG; Department of Medical and Molecular Genetics, King's College London, King's Health Partners Guy's Hospital, London SE1 9RT, UK.
  • Palmer CN; Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
  • Rautanen A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Sawcer SJ; Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
  • Trembath RC; Department of Medical and Molecular Genetics, King's College London, King's Health Partners Guy's Hospital, London SE1 9RT, UK.
  • Viswanathan AC; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHSFT and UCL Institute of Ophthalmology, London EC1V 2PD, UK.
  • Wood NW; Department of Molecular Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK.
  • Barroso I; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Peltonen L; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Dale PS; Department of Speech and Hearing Sciences, University of New Mexico, Albuquerque, New Mexico 87131, USA.
  • Petrill SA; Department of Family Science, Institute for Population Research, The Ohio State University, Columbus, Ohio 43210, USA.
  • Schalkwyk LS; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Craig IW; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Lewis CM; King's College London, Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, UK.
  • Price TS; Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5158, USA.
  • Donnelly P; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK.
Nat Commun ; 5: 4204, 2014 Jul 08.
Article em En | MEDLINE | ID: mdl-25003214
Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to children's ability in reading and mathematics, and estimate that around one half of the observed correlation in these traits is due to shared genetic effects (so-called Generalist Genes). Thus, our results highlight the potential role of the learning environment in contributing to differences in a child's cognitive abilities at age twelve.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leitura / Gêmeos / Característica Quantitativa Herdável / Dislexia / Genética Populacional / Matemática Limite: Child / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leitura / Gêmeos / Característica Quantitativa Herdável / Dislexia / Genética Populacional / Matemática Limite: Child / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2014 Tipo de documento: Article