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Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study.
Hong, Nam Soo; Kim, Jeong-Gook; Lee, Yu-Mi; Kim, Hyun-Woo; Kam, Sin; Kim, Keon-Yeop; Kim, Ki-Su; Lee, Duk-Hee.
Afiliação
  • Lee DH; Department of Preventative Medicine, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, South Korea. lee_dh@knu.ac.kr.
BMC Endocr Disord ; 14: 57, 2014 Jul 12.
Article em En | MEDLINE | ID: mdl-25015117
ABSTRACT

BACKGROUND:

Despite the consistent relationship between serum γ-glutamyltransferase (GGT) and type 2 diabetes (T2D), one unsolved issue is the role of serum GGT in the well-known association between obesity and T2D. This study was performed to investigate whether the association between body mass index (BMI) and impaired fasting glucose (IFG) differed depending on serum GGT levels within the normal range.

METHODS:

Study subjects were 2,424 men and 3,652 women aged ≥ 40, participating in the Fifth Korean National Health and Nutrition Examination Survey. Serum GGT levels within the normal range were classified into gender-specific tertiles.

RESULTS:

Among men and women belonging to the lowest tertile of serum GGT, BMI showed statistically non-significant weak associations with the risk of IFG. However, among persons in the highest tertile of serum GGT, the risk of IFG was 3 - 4 times higher among persons with BMI ≥ 25 kg/m2 than those with BMI < 23 kg/m2 (Pinteraction = 0.032 in men and 0.059 in women).

CONCLUSIONS:

The well-known strong association between BMI and IFG was observed mainly among persons with elevation of serum GGT to certain physiological levels, suggesting a critical role of serum GGT in the pathogenesis of IFG. This finding has an important clinical implication because serum GGT can be used to detect high-risk obese persons.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intolerância à Glucose / Diabetes Mellitus Tipo 2 / Gama-Glutamiltransferase / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: BMC Endocr Disord Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Intolerância à Glucose / Diabetes Mellitus Tipo 2 / Gama-Glutamiltransferase / Obesidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: BMC Endocr Disord Ano de publicação: 2014 Tipo de documento: Article