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Bone Morphogenetic Proteins: structure, biological function and therapeutic applications.
Carreira, Ana Claudia; Alves, Gutemberg Gomes; Zambuzzi, William Fernando; Sogayar, Mari Cleide; Granjeiro, José Mauro.
Afiliação
  • Carreira AC; Chemistry Institute, Biochemistry Department, University of São Paulo, São Paulo 05508-000, Brazil; NUCEL-NETCEM Cell and Molecular Therapy Center, Medical Clinics Department, School of Medicine, University of São Paulo, São Paulo, 05508-000 SP, Brazil. Electronic address: ancoc@iq.usp.br.
  • Alves GG; Cell and Molecular Biology Department, Institute of Biology, Fluminense Federal University, Niterói, RJ, Brazil. Electronic address: gutemberg.alves@id.uff.br.
  • Zambuzzi WF; Department of Chemistry and Biochemistry, Biosciences Institute, UNESP: Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address: wzambuzzi@ibb.unesp.br.
  • Sogayar MC; Chemistry Institute, Biochemistry Department, University of São Paulo, São Paulo 05508-000, Brazil; NUCEL-NETCEM Cell and Molecular Therapy Center, Medical Clinics Department, School of Medicine, University of São Paulo, São Paulo, 05508-000 SP, Brazil. Electronic address: mcsoga@iq.usp.br.
  • Granjeiro JM; Bioengineering Division, National Institute of Metrology, Quality, and Technology, Duque de Caxias, RJ, Brazil; Department of Dental Materials, Dental School, Fluminense Federal University, Niteroi, RJ, Brazil. Electronic address: jmgranjeiro@inmetro.gov.br.
Arch Biochem Biophys ; 561: 64-73, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25043976
ABSTRACT
Bone Morphogenetic Proteins (BMPs) are multifunctional secreted cytokines, which belong to the TGF-ß superfamily. These glycoproteins act as a disulfide-linked homo- or heterodimers, being potent regulators of bone and cartilage formation and repair, cell proliferation during embryonic development and bone homeostasis in the adult. BMPs are promising molecules for tissue engineering and bone therapy. The present review discusses this family of proteins, their structure and biological function, their therapeutic applications and drawbacks, their effects on mesenchymal stem cells differentiation, and the cell signaling pathways involved in this process.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Osso e Ossos / Comunicação Celular / Proteínas Morfogenéticas Ósseas / Engenharia Tecidual Limite: Animals / Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Osso e Ossos / Comunicação Celular / Proteínas Morfogenéticas Ósseas / Engenharia Tecidual Limite: Animals / Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2014 Tipo de documento: Article