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Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA.
Zuckerman, Jonathan E; Gritli, Ismael; Tolcher, Anthony; Heidel, Jeremy D; Lim, Dean; Morgan, Robert; Chmielowski, Bartosz; Ribas, Antoni; Davis, Mark E; Yen, Yun.
Afiliação
  • Zuckerman JE; Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;
  • Gritli I; College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan;
  • Tolcher A; South Texas Accelerated Research Therapeutics, San Antonio, TX 78229;
  • Heidel JD; Informulate, Madison, WI 53704;
  • Lim D; Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010;
  • Morgan R; Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010;
  • Chmielowski B; Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and.
  • Ribas A; Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; andJonsson Comprehensive Cancer Center, Los Angeles, CA 90095.
  • Davis ME; Chemical Engineering, California Institute of Technology, Pasadena, CA 91125; mdavis@cheme.caltech.edu yyen@coh.org.
  • Yen Y; College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan;Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010; mdavis@cheme.caltech.edu yyen@coh.org.
Proc Natl Acad Sci U S A ; 111(31): 11449-54, 2014 Aug 05.
Article em En | MEDLINE | ID: mdl-25049380
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / RNA Interferente Pequeno / Nanopartículas Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / RNA Interferente Pequeno / Nanopartículas Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article