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Determination of a novel phosphodiesterase4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass spectrometry.
Cho, Woon-Ki; Seo, Hyewon; Choi, Sung Heum; Kwak, Hyun Jeong; Cheon, Hyae Gyeong; Jeon, Dong Ju; Kim, Sang Kyum; Bae, Myung Ae; Song, Jin Sook.
Afiliação
  • Cho WK; Drug Discovery Platform Technology Group, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea; College of Pharmacy, ChungNam National University, Daejeon, Republic of Korea.
Biomed Chromatogr ; 29(3): 321-4, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25065367
A method for determining a novel phosphodiesterase-4 inhibitor, 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423), in rat plasma was developed and validated using liquid chromatography-tandem mass spectrometry for further pharmacokinetic study for development as a novel anti-asthmatic drug. PDE-423 in the concentration range of 0.02-10 µg/mL was linear with a correlation coefficient of >0.99, and the mean intra- and inter-assay precisions of the assay were 7.50 and 3.86%, respectively. The validated method was used successfully for a pharmacokinetic study of PDE-423 in rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Cromatografia Líquida / Espectrometria de Massas em Tandem / Inibidores da Fosfodiesterase 4 Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Cromatografia Líquida / Espectrometria de Massas em Tandem / Inibidores da Fosfodiesterase 4 Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2015 Tipo de documento: Article