Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.
Asian Pac J Trop Med
; 7(6): 483-7, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-25066399
ABSTRACT
OBJECTIVE:
To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.METHODS:
Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI.RESULTS:
According to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI 0.89-1.20) (P>0.05).CONCLUSIONS:
XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Predisposição Genética para Doença
/
Proteínas de Ligação a DNA
/
Neoplasias Pulmonares
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Asian Pac J Trop Med
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China