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Automated gait and balance parameters diagnose and correlate with severity in Parkinson disease.
Dewey, D Campbell; Miocinovic, Svjetlana; Bernstein, Ira; Khemani, Pravin; Dewey, Richard B; Querry, Ross; Chitnis, Shilpa; Dewey, Richard B.
Afiliação
  • Dewey DC; Department of Neurology, University of Texas Southwestern Medical Center, United States.
  • Miocinovic S; Department of Neurology, University of Texas Southwestern Medical Center, United States.
  • Bernstein I; Department of Clinical Sciences, University of Texas Southwestern Medical Center, United States.
  • Khemani P; Department of Neurology, University of Texas Southwestern Medical Center, United States.
  • Dewey RB; Department of Neurology, University of Texas Southwestern Medical Center, United States.
  • Querry R; Department of Physical Therapy, University of Texas Southwestern Medical Center, United States.
  • Chitnis S; Department of Neurology, University of Texas Southwestern Medical Center, United States.
  • Dewey RB; Department of Neurology, University of Texas Southwestern Medical Center, United States. Electronic address: Richard.dewey@utsouthwestern.edu.
J Neurol Sci ; 345(1-2): 131-8, 2014 Oct 15.
Article em En | MEDLINE | ID: mdl-25082782
OBJECTIVE: To assess the suitability of instrumented gait and balance measures for diagnosis and estimation of disease severity in PD. METHODS: Each subject performed iTUG (instrumented Timed-Up-and-Go) and iSway (instrumented Sway) using the APDM(®) Mobility Lab. MDS-UPDRS parts II and III, a postural instability and gait disorder (PIGD) score, the mobility subscale of the PDQ-39, and Hoehn & Yahr stage were measured in the PD cohort. Two sets of gait and balance variables were defined by high correlation with diagnosis or disease severity and were evaluated using multiple linear and logistic regressions, ROC analyses, and t-tests. RESULTS: 135 PD subjects and 66 age-matched controls were evaluated in this prospective cohort study. We found that both iTUG and iSway variables differentiated PD subjects from controls (area under the ROC curve was 0.82 and 0.75 respectively) and correlated with all PD severity measures (R(2) ranging from 0.18 to 0.61). Objective exam-based scores correlated more strongly with iTUG than iSway. The chosen set of iTUG variables was abnormal in very mild disease. Age and gender influenced gait and balance parameters and were therefore controlled in all analyses. INTERPRETATION: Our study identified sets of iTUG and iSway variables which correlate with PD severity measures and differentiate PD subjects from controls. These gait and balance measures could potentially serve as markers of PD progression and are under evaluation for this purpose in the ongoing NIH Parkinson Disease Biomarker Program.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos de Sensação / Transtornos Neurológicos da Marcha / Equilíbrio Postural Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtornos de Sensação / Transtornos Neurológicos da Marcha / Equilíbrio Postural Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Sci Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos