Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14&#945;-demethylase (CYP51).

Warrilow, Andrew G S; Hull, Claire M; Rolley, Nicola J; Parker, Josie E; Nes, W David; Smith, Stephen N; Kelly, Diane E; Kelly, Steven L

Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).

Warrilow, Andrew G S; Hull, Claire M; Rolley, Nicola J; Parker, Josie E; Nes, W David; Smith, Stephen N; Kelly, Diane E; Kelly, Steven L.

Afiliação

Warrilow AG; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Hull CM; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Rolley NJ; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Parker JE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Nes WD; Center for Chemical Biology, Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, USA.
Smith SN; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Kelly DE; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom d.kelly@swansea.ac.uk s.l.kelly@swansea.ac.uk.
Kelly SL; Centre for Cytochrome P450 Biodiversity, Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom d.kelly@swansea.ac.uk s.l.kelly@swansea.ac.uk.

Appl Environ Microbiol ; 80(19): 6154-66, 2014 Oct.

Article em En | MEDLINE | ID: mdl-25085484

Assuntos

Inibidores de 14-alfa Desmetilase/farmacologia; Antifúngicos/farmacologia; Clotrimazol/farmacologia; Doenças dos Peixes/tratamento farmacológico; Saprolegnia/efeitos dos fármacos; Animais; Antifúngicos/química; Azóis/química; Azóis/farmacologia; Vias Biossintéticas; Clotrimazol/química; Doenças dos Peixes/microbiologia; Peixes; Testes de Sensibilidade Microbiana/veterinária; Filogenia; Saprolegnia/enzimologia; Esterol 14-Desmetilase/química; Esterol 14-Desmetilase/genética; Esterol 14-Desmetilase/metabolismo; Esteróis/análise

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clotrimazol / Saprolegnia / Inibidores de 14-alfa Desmetilase / Doenças dos Peixes / Antifúngicos Limite: Animals Idioma: En Revista: Appl Environ Microbiol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido

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