Two novel toxin variants revealed by whole-genome sequencing of 175 Clostridium botulinum type E strains.
Appl Environ Microbiol
; 80(20): 6334-45, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25107978
ABSTRACT
We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Botulínicas
/
Clostridium botulinum tipo E
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Appl Environ Microbiol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Canadá