First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.

Saá, Paula; Yakovleva, Oksana; de Castro, Jorge; Vasilyeva, Irina; De Paoli, Silvia H; Simak, Jan; Cervenakova, Larisa

Saá, Paula; Yakovleva, Oksana; de Castro, Jorge; Vasilyeva, Irina; De Paoli, Silvia H; Simak, Jan; Cervenakova, Larisa.

Afiliação

Saá P; From the Transmissible Diseases Department, Biomedical Services Holland Laboratory, American National Red Cross, Rockville, Maryland 20855 and Paula.Saa@redcross.org.
Yakovleva O; From the Transmissible Diseases Department, Biomedical Services Holland Laboratory, American National Red Cross, Rockville, Maryland 20855 and.
de Castro J; From the Transmissible Diseases Department, Biomedical Services Holland Laboratory, American National Red Cross, Rockville, Maryland 20855 and.
Vasilyeva I; From the Transmissible Diseases Department, Biomedical Services Holland Laboratory, American National Red Cross, Rockville, Maryland 20855 and.
De Paoli SH; the Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993.
Simak J; the Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993.
Cervenakova L; From the Transmissible Diseases Department, Biomedical Services Holland Laboratory, American National Red Cross, Rockville, Maryland 20855 and.

J Biol Chem ; 289(42): 29247-60, 2014 Oct 17.

Article em En | MEDLINE | ID: mdl-25157106

Assuntos

Doenças Priônicas/metabolismo; Príons/metabolismo; Animais; Plaquetas/metabolismo; Células Cultivadas; Síndrome de Creutzfeldt-Jakob/metabolismo; Meios de Cultivo Condicionados/química; Endopeptidase K/química; Exossomos/metabolismo; Proteínas de Choque Térmico HSP70/metabolismo; Imunoglobulina G/química; Metanol/química; Camundongos; Camundongos Endogâmicos C57BL; Nanopartículas/química; Desnaturação Proteica; Dobramento de Proteína

Palavras-chave

Blood; Cell Culture; Exosome; Extracellular Vesicles; Mouse

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Doenças Priônicas Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

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