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Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population.
Cao, D-L; Gu, C-Y; Zhu, Y; Dai, B; Zhang, H-L; Shi, G-H; Shen, Y-J; Zhu, Y-P; Ma, C-G; Xiao, W-J; Qin, X-J; Lin, G-W; Ye, D-W.
Afiliação
  • Cao DL; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Gu CY; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhu Y; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Dai B; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhang HL; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Shi GH; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Shen YJ; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhu YP; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Ma CG; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Xiao WJ; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Qin XJ; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Lin GW; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Ye DW; 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Prostate Cancer Prostatic Dis ; 17(4): 315-9, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25224557
ABSTRACT

BACKGROUND:

Controversial data on the association of single-nucleotide polymorphisms (SNPs, rs3787016G>A and rs10773338G>A) in long non-coding RNA (lncRNA) with prostate cancer risk were emerged. Considering possible genetic differences among populations, we conducted the present study to clarify these discrepancies and re-validate these results in an eastern Chinese population and thus provide clues for new therapeutic targets of prostate cancer.

METHODS:

Genotypes of these two SNPs from 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls were determined by Taqman assays. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for risk associations.

RESULTS:

The association of rs3787016 A variant genotypes with a significantly higher prostate cancer risk were found (adjusted OR = 1.418, 95% CI = 1.090-1.844 for AA vs GG). Stratification analysis indicated that the risk of rs3787016 variant AG/AA genotypes was more evident in younger subjects, ever smoking, patients with Gleason score ⩾ 7(4+3) and highly aggressive status. All these risks were not present for rs10773338G>A.

CONCLUSIONS:

These findings suggested that lncRNA SNPs may contribute to prostate cancer risk in an eastern Chinese population. Larger and well-designed studies with different ethnic populations are warranted to validate our findings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Povo Asiático / RNA Longo não Codificante Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Prostate Cancer Prostatic Dis Assunto da revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Povo Asiático / RNA Longo não Codificante Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Prostate Cancer Prostatic Dis Assunto da revista: ENDOCRINOLOGIA / NEOPLASIAS / UROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China