Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
Surgery
; 105(5): 690-2, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2523092
ABSTRACT
A 62-year-old man arrived at our hospital with recurrence of Cushing's syndrome 14 years after successful surgery for adrenocortical carcinoma. Investigations demonstrated recurrence of a large tumor above the right adrenal area; it was found to be inoperable. The patient was treated initially with a new glucocorticoid antagonist, RU 486, and later with the adrenolytic agent mitotane (o,p'DDD). The latter achieved hypoadrenocorticism and a substantial reduction of tumor size. During the initial period, worsening hyperadrenocorticism resulted in a rise of atrial natriuretic factor and an inhibition of renin activity, consistent with an increase of cortisol and plasma volume. Changes in opposite direction were observed after treatment with mitotane.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Fator Natriurético Atrial
/
Neoplasias das Glândulas Suprarrenais
/
Síndrome de Cushing
/
Mitotano
/
Recidiva Local de Neoplasia
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Surgery
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Bélgica