Your browser doesn't support javascript.
loading
Genome-wide scan of 29,141 African Americans finds no evidence of directional selection since admixture.
Bhatia, Gaurav; Tandon, Arti; Patterson, Nick; Aldrich, Melinda C; Ambrosone, Christine B; Amos, Christopher; Bandera, Elisa V; Berndt, Sonja I; Bernstein, Leslie; Blot, William J; Bock, Cathryn H; Caporaso, Neil; Casey, Graham; Deming, Sandra L; Diver, W Ryan; Gapstur, Susan M; Gillanders, Elizabeth M; Harris, Curtis C; Henderson, Brian E; Ingles, Sue A; Isaacs, William; De Jager, Phillip L; John, Esther M; Kittles, Rick A; Larkin, Emma; McNeill, Lorna H; Millikan, Robert C; Murphy, Adam; Neslund-Dudas, Christine; Nyante, Sarah; Press, Michael F; Rodriguez-Gil, Jorge L; Rybicki, Benjamin A; Schwartz, Ann G; Signorello, Lisa B; Spitz, Margaret; Strom, Sara S; Tucker, Margaret A; Wiencke, John K; Witte, John S; Wu, Xifeng; Yamamura, Yuko; Zanetti, Krista A; Zheng, Wei; Ziegler, Regina G; Chanock, Stephen J; Haiman, Christopher A; Reich, David; Price, Alkes L.
Afiliação
  • Bhatia G; Division of Health, Science, and Technology, the Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA. Electronic address: gbhatia@mit.edu.
  • Tandon A; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Patterson N; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
  • Aldrich MC; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, TN 372
  • Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
  • Amos C; Section of Biostatistics and Epidemiology, Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03766, USA.
  • Bandera EV; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
  • Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Bernstein L; Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, CA 91010, USA.
  • Blot WJ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; International Epidemiology Institute, Rockville, MD 20850, USA.
  • Bock CH; Karmanos Cancer Institute and Department of Oncology, Wayne State University of Medicine, Detroit, MI 48201, USA.
  • Caporaso N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Casey G; Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
  • Deming SL; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Diver WR; Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
  • Gapstur SM; Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
  • Gillanders EM; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
  • Harris CC; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Henderson BE; Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
  • Ingles SA; Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
  • Isaacs W; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institutions, Baltimore, MD 21287, USA.
  • De Jager PL; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and W
  • John EM; Cancer Prevention Institute of California, Fremont, CA 94538, USA; Stanford Cancer Center, Stanford Medicine, Stanford, CA 94305, USA.
  • Kittles RA; Department of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Larkin E; Division of Allergy, Pulmonary, and Critical Care, Department of Medicine, Vanderbilt University Medical Center, 6100 Medical Center East, Nashville, TN 37232-8300, USA.
  • McNeill LH; Department of Health Disparities Research, Cancer Prevention and Population Sciences, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; Center for Community Implementation and Dissemination Research, Duncan Family Institute, the University of Texas M.D. Anderson Cancer Cen
  • Millikan RC; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Murphy A; Department of Urology, Northwestern University, Chicago, IL 60611, USA.
  • Neslund-Dudas C; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
  • Nyante S; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Press MF; Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
  • Rodriguez-Gil JL; Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA.
  • Schwartz AG; Karmanos Cancer Institute and Department of Oncology, Wayne State University of Medicine, Detroit, MI 48201, USA.
  • Signorello LB; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA; International Epidemiology Institute, Rockville, MD 20850, USA.
  • Spitz M; Section of Biostatistics and Epidemiology, Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03766, USA.
  • Strom SS; Department of Epidemiology, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
  • Tucker MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Wiencke JK; University of California, San Francisco, San Francisco, CA 94158, USA.
  • Witte JS; Departments of Epidemiology and Biostatistics and Urology, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Wu X; Section of Biostatistics and Epidemiology, Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH 03766, USA.
  • Yamamura Y; Department of Epidemiology, the University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
  • Zanetti KA; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, TN 37203, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
  • Ziegler RG; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Haiman CA; Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.
  • Reich D; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
  • Price AL; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA; Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Am J Hum Genet ; 95(4): 437-44, 2014 Oct 02.
Article em En | MEDLINE | ID: mdl-25242497
ABSTRACT
The extent of recent selection in admixed populations is currently an unresolved question. We scanned the genomes of 29,141 African Americans and failed to find any genome-wide-significant deviations in local ancestry, indicating no evidence of selection influencing ancestry after admixture. A recent analysis of data from 1,890 African Americans reported that there was evidence of selection in African Americans after their ancestors left Africa, both before and after admixture. Selection after admixture was reported on the basis of deviations in local ancestry, and selection before admixture was reported on the basis of allele-frequency differences between African Americans and African populations. The local-ancestry deviations reported by the previous study did not replicate in our very large sample, and we show that such deviations were expected purely by chance, given the number of hypotheses tested. We further show that the previous study's conclusion of selection in African Americans before admixture is also subject to doubt. This is because the FST statistics they used were inflated and because true signals of unusual allele-frequency differences between African Americans and African populations would be best explained by selection that occurred in Africa prior to migration to the Americas.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Genoma Humano / Cromossomos Humanos / Polimorfismo de Nucleotídeo Único / População Negra / Estudo de Associação Genômica Ampla / Genética Populacional Limite: Humans Idioma: En Revista: Am J Hum Genet Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Genoma Humano / Cromossomos Humanos / Polimorfismo de Nucleotídeo Único / População Negra / Estudo de Associação Genômica Ampla / Genética Populacional Limite: Humans Idioma: En Revista: Am J Hum Genet Ano de publicação: 2014 Tipo de documento: Article