Shigella hacks host immune responses by reprogramming the host epigenome.

Ashida, Hiroshi; Sasakawa, Chihiro

Ashida, Hiroshi; Sasakawa, Chihiro.

Afiliação

Ashida H; Division of Bacterial Infection Biology, Institute of Medical Science, University of Tokyo, Minato-ku Tokyo, Japan.
Sasakawa C; Division of Bacterial Infection Biology, Institute of Medical Science, University of Tokyo, Minato-ku Tokyo, Japan Nippon Institute for Biological Science, Ome Tokyo, Japan Medical Mycology Research Center, Chiba University, Chuo-ku Chiba, Japan.

EMBO J ; 33(22): 2598-600, 2014 Nov 18.

Article em En | MEDLINE | ID: mdl-25246515

ABSTRACT

ABSTRACT

Bacterial pathogens alter host transcriptional programs to promote infection. Shigella OspF is an essential virulence protein with a unique phosphothreonine lyase activity. A new study in The EMBO Journal (Harouz et al, 2014) reveals a novel function of OspF targeting of heterochromatin protein 1Î³ (HP1Î³) and downregulation of a subset of immune genes. These results illustrate how bacterial pathogens exploit epigenetic modifications to counteract host immune responses.

Assuntos

Proteínas da Membrana Bacteriana Externa/metabolismo; Carbono-Oxigênio Liases/metabolismo; Proteínas Cromossômicas não Histona/metabolismo; Disenteria Bacilar/metabolismo; Enterocolite/metabolismo; Shigella flexneri/metabolismo; Transcriptoma; Animais; Homólogo 5 da Proteína Cromobox

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Shigella flexneri / Proteínas da Membrana Bacteriana Externa / Proteínas Cromossômicas não Histona / Carbono-Oxigênio Liases / Disenteria Bacilar / Enterocolite / Transcriptoma Limite: Animals Idioma: En Revista: EMBO J Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Japão

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