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An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.
Macauley, Shannon L; Wong, Andrew M S; Shyng, Charles; Augner, David P; Dearborn, Joshua T; Pearse, Yewande; Roberts, Marie S; Fowler, Stephen C; Cooper, Jonathan D; Watterson, D Martin; Sands, Mark S.
Afiliação
  • Macauley SL; Department of Neurology, Department of Internal Medicine, and.
  • Wong AM; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and.
  • Shyng C; Department of Internal Medicine, and.
  • Augner DP; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and.
  • Dearborn JT; Department of Internal Medicine, and.
  • Pearse Y; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and.
  • Roberts MS; Department of Internal Medicine, and.
  • Fowler SC; Departments of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045.
  • Cooper JD; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, London SE5 9NU, United Kingdom, and.
  • Watterson DM; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
  • Sands MS; Department of Internal Medicine, and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, msands@dom.wustl.edu.
J Neurosci ; 34(39): 13077-82, 2014 Sep 24.
Article em En | MEDLINE | ID: mdl-25253854
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioléster Hidrolases / Barreira Hematoencefálica / Terapia Genética / Microglia / Lipofuscinoses Ceroides Neuronais Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioléster Hidrolases / Barreira Hematoencefálica / Terapia Genética / Microglia / Lipofuscinoses Ceroides Neuronais Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2014 Tipo de documento: Article