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African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.
Roses, Allen D; Lutz, Michael W; Saunders, Ann M; Goldgaber, Dmitry; Saul, Robert; Sundseth, Scott S; Akkari, P Anthony; Roses, Stephanie M; Gottschalk, W Kirby; Whitfield, Keith E; Vostrov, Alexander A; Hauser, Michael A; Allingham, R Rand; Burns, Daniel K; Chiba-Falek, Ornit; Welsh-Bohmer, Kathleen A.
Afiliação
  • Roses AD; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA; Zinfandel Pharmaceuticals Inc, Chapel Hill, NC, USA; Cabernet Pharmaceuticals, Inc., Chapel Hill, NC, USA. Electronic address: allen.roses@duke.edu.
  • Lutz MW; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
  • Saunders AM; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
  • Goldgaber D; Department of Psychiatry, State University of New York, Stony Brook, NY, USA.
  • Saul R; Polymorphic DNA Technologies, Alameda, CA, USA.
  • Sundseth SS; Cabernet Pharmaceuticals, Inc., Chapel Hill, NC, USA.
  • Akkari PA; Cabernet Pharmaceuticals, Inc., Chapel Hill, NC, USA.
  • Roses SM; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
  • Gottschalk WK; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
  • Whitfield KE; Department of Psychology, Duke University, Durham, NC, USA.
  • Vostrov AA; Department of Psychiatry, State University of New York, Stony Brook, NY, USA.
  • Hauser MA; Center for Genetic Diseases, Duke University, Durham, NC, USA.
  • Allingham RR; Department of Ophthalmology, Duke University, Durham, NC, USA.
  • Burns DK; Zinfandel Pharmaceuticals Inc, Chapel Hill, NC, USA.
  • Chiba-Falek O; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
  • Welsh-Bohmer KA; Duke University Bryan Alzheimer's Disease Research Center, Duke University, Durham, NC, USA.
Alzheimers Dement ; 10(6): 592-601.e2, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25260913
ABSTRACT

BACKGROUND:

Several studies have demonstrated a lower apolipoprotein E4 (APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes.

METHODS:

We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts.

RESULTS:

African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE ε4 or APOE ε3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE ε4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians.

CONCLUSION:

These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Proteínas de Membrana Transportadoras / População Negra / População Branca Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Africa / America do norte Idioma: En Revista: Alzheimers Dement Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Proteínas de Membrana Transportadoras / População Negra / População Branca Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Africa / America do norte Idioma: En Revista: Alzheimers Dement Ano de publicação: 2014 Tipo de documento: Article