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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.
Bertin, Samuel; Aoki-Nonaka, Yukari; de Jong, Petrus Rudolf; Nohara, Lilian L; Xu, Hongjian; Stanwood, Shawna R; Srikanth, Sonal; Lee, Jihyung; To, Keith; Abramson, Lior; Yu, Timothy; Han, Tiffany; Touma, Ranim; Li, Xiangli; González-Navajas, José M; Herdman, Scott; Corr, Maripat; Fu, Guo; Dong, Hui; Gwack, Yousang; Franco, Alessandra; Jefferies, Wilfred A; Raz, Eyal.
Afiliação
  • Bertin S; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Aoki-Nonaka Y; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • de Jong PR; Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, 5274 Gakkocho 2-ban-cho, Chuo-ku, Niigata 951-8514, Japan.
  • Nohara LL; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Xu H; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
  • Stanwood SR; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
  • Srikanth S; Michael Smith Laboratories; Centre for Blood Research; The Brain Research Centre; Department of Medical Genetics; Department of Microbiology and Immunology; Department of Zoology, University of British Columbia, Vancouver, BC, Canada.
  • Lee J; Department of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • To K; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Abramson L; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Yu T; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Han T; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Touma R; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Li X; Department of Pediatrics University of California, San Diego, La Jolla, CA 92093, USA.
  • González-Navajas JM; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Herdman S; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Corr M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Fu G; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Dong H; Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Gwack Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian 361102, China.
  • Franco A; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Jefferies WA; Department of Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Raz E; Department of Pediatrics University of California, San Diego, La Jolla, CA 92093, USA.
Nat Immunol ; 15(11): 1055-1063, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25282159
TRPV1 is a Ca(2+)-permeable channel studied mostly as a pain receptor in sensory neurons. However, its role in other cell types is poorly understood. Here we found that TRPV1 was functionally expressed in CD4(+) T cells, where it acted as a non-store-operated Ca(2+) channel and contributed to T cell antigen receptor (TCR)-induced Ca(2+) influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. Furthermore, genetic and pharmacological inhibition of TRPV1 in human CD4(+) T cells recapitulated the phenotype of mouse Trpv1(-/-) CD4(+) T cells. Our findings suggest that inhibition of TRPV1 could represent a new therapeutic strategy for restraining proinflammatory T cell responses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Receptores de Antígenos de Linfócitos T / Linfócitos T CD4-Positivos / Canais de Cátion TRPV / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Receptores de Antígenos de Linfócitos T / Linfócitos T CD4-Positivos / Canais de Cátion TRPV / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos