Age-related changes in contact photosensitivity differ among mouse strains.
Mech Ageing Dev
; 49(2): 137-46, 1989 Aug.
Article
em En
| MEDLINE
| ID: mdl-2529401
ABSTRACT
There are differences among mouse strains in the age-related changes in reactivity to the contact photosensitizer tetrachlorosalicylanilide (TCSA). We found a tendency to lower reactions in older mice, with some strains showing declines from an early age (BALB/cJ, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J). Others had increasing reactions until about 30-50 weeks of age before declining (DBA/1J, C3H/HeJ, and A/J) and one strain (C57BL/6J) had increased reactivity with age. There are also differences in the role of cyclophosphamide-sensitive T-suppressor cells in these age-related changes. In some mouse strains, BALB/cJ, C57BL/6J, A/J, DBA/1J and C3H/HeJ, age-related changes in reactivity to TCSA are independent of changes in cyclophosphamide-sensitive suppressor cells. In other strains, MRL/MpJ +/+, MRL/MpJ lpr/lpr and SJL/J, the development of cyclophosphamide-sensitive suppressor cells is responsible for the initial, though not later, stages of the age-related decline in reactivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Fotossensibilidade
/
Salicilanilidas
/
Envelhecimento
/
Alérgenos
/
Salicilamidas
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Canadá