A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
Small
; 11(8): 919-25, 2015 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-25318658
ABSTRACT
A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py-Cbl), a water-soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy-poly(ethylene glycol)114 -block-poly(L -lysine hydrochloride)200. This DDS successfully addresses three important issues enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pró-Fármacos
/
Sistemas de Liberação de Medicamentos
/
Nanocápsulas
/
Compostos de Amônio Quaternário
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Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Small
Assunto da revista:
ENGENHARIA BIOMEDICA
Ano de publicação:
2015
Tipo de documento:
Article