Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models.

Leong, Lilley; Sim, Derek; Patel, Chandra; Tran, Katherine; Liu, Perry; Ho, Elena; Thompson, Thomas; Kretschmer, Peter J; Wakabayashi, Hironao; Fay, Philip J; Murphy, John E

Leong, Lilley; Sim, Derek; Patel, Chandra; Tran, Katherine; Liu, Perry; Ho, Elena; Thompson, Thomas; Kretschmer, Peter J; Wakabayashi, Hironao; Fay, Philip J; Murphy, John E.

Afiliação

Leong L; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Sim D; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Patel C; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Tran K; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Liu P; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Ho E; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Thompson T; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Kretschmer PJ; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.
Wakabayashi H; Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, NY.
Fay PJ; Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, NY.
Murphy JE; Bayer HealthCare Pharmaceuticals, US Innovation Center, San Francisco, CA; and.

Blood ; 125(2): 392-8, 2015 Jan 08.

Article em En | MEDLINE | ID: mdl-25331117

Assuntos

Fator VIII/química; Fator VIII/farmacologia; Hemofilia A/genética; Animais; Arteríolas/lesões; Modelos Animais de Doenças; Fator VIII/genética; Feminino; Camundongos; Camundongos Knockout; Estabilidade Proteica; Estrutura Terciária de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Hemofilia A Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2015 Tipo de documento: Article

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