The general mode of translation inhibition by macrolide antibiotics.

Kannan, Krishna; Kanabar, Pinal; Schryer, David; Florin, Tanja; Oh, Eugene; Bahroos, Neil; Tenson, Tanel; Weissman, Jonathan S; Mankin, Alexander S

Kannan, Krishna; Kanabar, Pinal; Schryer, David; Florin, Tanja; Oh, Eugene; Bahroos, Neil; Tenson, Tanel; Weissman, Jonathan S; Mankin, Alexander S.

Afiliação

Kannan K; Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607;
Kanabar P; Center for Research Informatics (CRI), Research Resources Center, University of Illinois, Chicago, IL 60612;
Schryer D; Institute of Technology, University of Tartu, 50411 Tartu, Estonia;
Florin T; Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607; Institute of Biochemistry and Biology, University of Potsdam, D-14424 Potsdam, Germany; and.
Oh E; Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158.
Bahroos N; Center for Research Informatics (CRI), Research Resources Center, University of Illinois, Chicago, IL 60612;
Tenson T; Institute of Technology, University of Tartu, 50411 Tartu, Estonia;
Weissman JS; Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158.
Mankin AS; Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607; shura@uic.edu.

Proc Natl Acad Sci U S A ; 111(45): 15958-63, 2014 Nov 11.

Article em En | MEDLINE | ID: mdl-25349425

Assuntos

Antibacterianos/farmacologia; Códon/metabolismo; Proteínas de Escherichia coli/biossíntese; Escherichia coli/metabolismo; Macrolídeos/farmacologia; Ribossomos/metabolismo; Códon/genética; Escherichia coli/genética; Proteínas de Escherichia coli/genética; Estudo de Associação Genômica Ampla; Biossíntese de Proteínas; Ribossomos/genética

Palavras-chave

antibiotics; macrolides; peptidyl transferase; ribosome; translation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribossomos / Códon / Macrolídeos / Proteínas de Escherichia coli / Escherichia coli / Antibacterianos Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article

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