Longitudinal PET-MRI reveals ß-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion.
Nat Med
; 20(12): 1485-92, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25384087
ABSTRACT
The dynamics of ß-amyloid deposition and related second-order physiological effects, such as regional cerebral blood flow (rCBF), are key factors for a deeper understanding of Alzheimer's disease (AD). We present longitudinal in vivo data on the dynamics of ß-amyloid deposition and the decline of rCBF in two different amyloid precursor protein (APP) transgenic mouse models of AD. Using a multiparametric positron emission tomography and magnetic resonance imaging approach, we demonstrate that in the presence of cerebral ß-amyloid angiopathy (CAA), ß-amyloid deposition is accompanied by a decline of rCBF. Loss of perfusion correlates with the growth of ß-amyloid plaque burden but is not related to the number of CAA-induced microhemorrhages. However, in a mouse model of parenchymal ß-amyloidosis and negligible CAA, rCBF is unchanged. Because synaptically driven spontaneous network activity is similar in both transgenic mouse strains, we conclude that the disease-related decline of rCBF is caused by CAA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Hemorragia Cerebral
/
Circulação Cerebrovascular
/
Peptídeos beta-Amiloides
/
Angiopatia Amiloide Cerebral
/
Placa Amiloide
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha