RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation.
Nature
; 517(7532): 33-8, 2015 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-25409156
ABSTRACT
Emerging evidence suggests that the ribosome has a regulatory function in directing how the genome is translated in time and space. However, how this regulation is encoded in the messenger RNA sequence remains largely unknown. Here we uncover unique RNA regulons embedded in homeobox (Hox) 5' untranslated regions (UTRs) that confer ribosome-mediated control of gene expression. These structured RNA elements, resembling viral internal ribosome entry sites (IRESs), are found in subsets of Hox mRNAs. They facilitate ribosome recruitment and require the ribosomal protein RPL38 for their activity. Despite numerous layers of Hox gene regulation, these IRES elements are essential for converting Hox transcripts into proteins to pattern the mammalian body plan. This specialized mode of IRES-dependent translation is enabled by an additional regulatory element that we term the translation inhibitory element (TIE), which blocks cap-dependent translation of transcripts. Together, these data uncover a new paradigm for ribosome-mediated control of gene expression and organismal development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribossomos
/
Regulação da Expressão Gênica
/
Genes Homeobox
/
Regiões 5' não Traduzidas
/
Sequências Reguladoras de Ácido Ribonucleico
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos