[Effects of Shenmai injection on afterdepolarization and triggered activities in left ventricular papillary muscle in rat cardiac hypertrophy].
Zhongguo Zhong Yao Za Zhi
; 39(15): 2956-9, 2014 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-25423840
ABSTRACT
This study is to evaluate the effects of Shenmai injection on the temporal alterations of action potential (AP), early afterdepolarization (EAD) and delayed afterdepolarization (DAD) in papillary muscles. The action potentials were recorded by a glass electrode. APD at 90% repolarization (APD9 ) was measured, and spontaneous EAD and DAD were observed. The results show APD90 was significantly prolonged in model group compared with sham-operated group, whereas it was remained unchanged in Shenmai injec- tion treatment group and amiodarone group. The spontaneous EADs and DADs were frequently visible in model group. In conclusion, EAD, DAD and trigger activities increase gradually during pathological progression of rat cardiac hypertrophy, and Shenmai injection could improve the action potential change in rat cardiac hypertrophy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Músculos Papilares
/
Potenciais de Ação
/
Medicamentos de Ervas Chinesas
/
Cardiomegalia
/
Ventrículos do Coração
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2014
Tipo de documento:
Article