Synthesis and SAR of thieno[3,2-b]pyridinyl urea derivatives as urotensin-II receptor antagonists.

Lim, Chae Jo; Oh, Seung Ae; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang

Lim, Chae Jo; Oh, Seung Ae; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang.

Afiliação

Lim CJ; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon 305-343, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Yuseong-gu, Daejeon 305-350, Republic of Korea.
Oh SA; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon 305-343, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Yuseong-gu, Daejeon 305-350, Republic of Korea.
Lee BH; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon 305-343, Republic of Korea.
Oh KS; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon 305-343, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Yuseong-gu, Daejeon 305-350, Republic of Korea.
Yi KY; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon 305-343, Republic of Korea; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, Yuseong-gu, Daejeon 305-350, Republic of Korea. Electronic address: kyyi@k

Bioorg Med Chem Lett ; 24(24): 5832-5835, 2014 Dec 15.

Article em En | MEDLINE | ID: mdl-25452001

Assuntos

Piridinas/química; Receptores Acoplados a Proteínas G/antagonistas & inibidores; Tiofenos/síntese química; Ureia/análogos & derivados; Animais; Canal de Potássio ERG1; Canais de Potássio Éter-A-Go-Go/química; Canais de Potássio Éter-A-Go-Go/metabolismo; Humanos; Microssomos Hepáticos/metabolismo; Ligação Proteica; Ratos; Receptores Acoplados a Proteínas G/metabolismo; Relação Estrutura-Atividade; Tiofenos/química; Tiofenos/metabolismo; Ureia/síntese química; Ureia/química; Ureia/metabolismo

Palavras-chave

Antagonists; Cardiovascular disease; Thieno[3,2-b]pyridinyl urea; Urotensin-II receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Tiofenos / Ureia / Receptores Acoplados a Proteínas G Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article

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