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A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.
Hill, Richard; Kalathur, Ravi Kiran Reddy; Callejas, Sergio; Colaço, Laura; Brandão, Ricardo; Serelde, Beatriz; Cebriá, Antonio; Blanco-Aparicio, Carmen; Pastor, Joaquín; Futschik, Matthias; Dopazo, Ana; Link, Wolfgang.
Afiliação
  • Hill R; IBB-Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine (CBME), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. drrjhill@gmail.com.
  • Kalathur RK; Regenerative Medicine Program, Department of Biomedical Sciences and Medicine, University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. drrjhill@gmail.com.
  • Callejas S; IBB-Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine (CBME), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. ravikiran.k@gmail.com.
  • Colaço L; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. scallejas@cnic.es.
  • Brandão R; IBB-Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine (CBME), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. lauracolaco21@gmail.com.
  • Serelde B; IBB-Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine (CBME), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. r.brandao13@gmail.com.
  • Cebriá A; Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. bserelde@cnio.es.
  • Blanco-Aparicio C; Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. acebria@cnio.es.
  • Pastor J; Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. cblanco@cnio.es.
  • Futschik M; Experimental Therapeutics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. jpastor@cnio.es.
  • Dopazo A; IBB-Institute for Biotechnology and Bioengineering, Centre for Molecular and Structural Biomedicine (CBME), University of Algarve, Campus de Gambelas, 8005-139, Faro, Portugal. mfutschik@ualg.pt.
  • Link W; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle de Melchor Fernández Almagro 3, 28029, Madrid, Spain. adopazo@cnic.es.
Breast Cancer Res ; 16(6): 482, 2014 Dec 09.
Article em En | MEDLINE | ID: mdl-25488803
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Neoplasias da Mama / Adenocarcinoma / Proliferação de Células / Proteínas Proto-Oncogênicas c-akt / Fatores de Transcrição Forkhead / Pontos de Checagem do Ciclo Celular / Inibidores de Fosfoinositídeo-3 Quinase Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Portugal
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Neoplasias da Mama / Adenocarcinoma / Proliferação de Células / Proteínas Proto-Oncogênicas c-akt / Fatores de Transcrição Forkhead / Pontos de Checagem do Ciclo Celular / Inibidores de Fosfoinositídeo-3 Quinase Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Breast Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Portugal