Recording of brain activity across spatial scales.
Curr Opin Neurobiol
; 32: 68-77, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25544724
ABSTRACT
Brain activity reveals exquisite coordination across spatial scales, from local microcircuits to brain-wide networks. Understanding how the brain represents, transforms and communicates information requires simultaneous recordings from distributed nodes of whole brain networks with single-cell resolution. Realizing multi-site recordings from communicating populations is hampered by the need to isolate clusters of interacting cells, often on a day-to-day basis. Chronic implantation of multi-electrode arrays allows long-term tracking of activity. Lithography on thin films provides a means to produce arrays of variable resolution, a high degree of flexibility, and minimal tissue displacement. Sequential application of surface arrays to monitor activity across brain-wide networks and subsequent implantation of laminar arrays to target specific populations enables continual refinement of spatial scale while maintaining coverage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Eletrodos Implantados
/
Fenômenos Eletrofisiológicos
/
Rede Nervosa
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Neurobiol
Assunto da revista:
BIOLOGIA
/
NEUROLOGIA
Ano de publicação:
2015
Tipo de documento:
Article