Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro.
Mol Cell Biol
; 9(12): 5718-21, 1989 Dec.
Article
em En
| MEDLINE
| ID: mdl-2555704
ABSTRACT
Ets1 and Ets2 are nuclear phosphoproteins which bind to DNA in vitro and share two domains of strong identity. Deletion analyses of each of these conserved regions in Ets1 demonstrated that integrity of the carboxy-terminal domain, also conserved in the more distantly related elk and erg gene products, is essential for both nuclear targeting and DNA-binding activity in vitro.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Tirosina Quinases
/
Proteínas Nucleares
/
Proteínas Proto-Oncogênicas
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
França